This study presented an experimental and numerical investigation focused on pier segments of segmental bridge types. The pier segments were constructed to represent Lak Si Overpass Highway Route No. 304, Thailand. The experimental program included five pier segments with similar reinforcement details but varying concrete strengths. The numerical work validated the finite element model (FEM) using experimental results and conducted a parametric study to assess the impact of steel reinforcement variation and concrete compressive strength on the bursting capacity of pier segments. Key findings included a consistent failure pattern characterized by a prominent vertical crack and concrete crushing at the bottom, particularly in specimens with lower concrete strength. The bursting loads exhibited a decrease corresponding to a reduction in compressive strength, with up to a 20% decrease observed when strength was reduced by 20%. The finite element analysis (FEA) results slightly surpassed experimental findings, yet the marginal discrepancies confirmed the accuracy of the advanced tool for engineering nonlinear analysis (ATENA) computer program in predicting bursting forces. The parametric study highlighted a substantial increase in bursting loads with variations in concrete strength and the number of steel reinforcement layers, with a non-proportional relationship between bursting load and concrete strength.