pH and Electromagnetic Dual-Remoted Drug Delivery Based on Bimodal Superparamagnetic Fe3O4@Porous Silica Nanoparticles
Haihua Hu, Haopeng Liu, Dianjun Zhang, Jianjun Wang, Gaowu Qin and Xuefeng Zhang
1 Key Laboratory for Anisotropy and Texture of Materials (ME), School of Materials Science and Engineering, Northeastern University, Shenyang, 110819, China
2 Innovative Center of Advanced Materials, Hangzhou Dianzi University, Hangzhou, 310018, China
3 Shenyang Northeastern Institute of Metal Materials Co., Ltd, Shenyang, 110108, China
Abstract
We developed a molecular-grafting procedure to the synthesis of ultrathin Fe3O4 decorated Fe3O4/silica core/shell nanoparticles. Such nanoparticles demonstrated superparamagnetic transitions at temperatures of 14 K and 213 K and weak magnetic interactions between the decorated ultrathin Fe3O4 and Fe3O4 cores. When evaluated for the electromagnetically/pH switchable drug delivery, the Fe3O4/silica/Fe3O4 nanoparticles manifest a better controllability for enhancing the drug release than the Fe3O4/silica nanoparticles, ascribed to the bimodal hyperthermia effect of internal ~10 nm Fe3O4 cores and externally decorated ~2.5 nm Fe3O4 nanoparticles.
Publication details
Received: 11 Apr 2018
Accepted: 23 Apr 2018
Published online: 24 Apr 2018
Article type:
Research Paper
DOI:
10.30919/es8d136
Volume:
2
Page:
43-48
Citation:
Engineered Science, 2018, 2, 43-48
Permissions:
Copyright
Number of downloads:
6037
Citation Information:
16
Description:
Bimodal superparamagnetic Fe3O4@porous silica nanoparticles for the efficient control of drug delive....
Bimodal superparamagnetic Fe3O4@porous silica nanoparticles for the efficient control of drug delivery triggered by synergistic electromagnetic field and pH.
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