The objective of this study is to determine how policies for stay-at-home (lockdown) and phases of easing the lockdown, implemented by the Government of Ghana to slow the spread of COVID-19, impacted traffic emissions and ambient concentrations of particulate matter (PM10, PM2.5). Monthly data was collected from January 2020 to June 2020from four roadside monitoring locations using Mini Vol Air Samplers. High-volume ambient samplers were used to collect PM data at two permanent (industrial and residential) locations. Monthly concentrations were plotted versus time over the six-month period. Results showed that PM2.5 concentrations decreased over Greater Accra in the month of April during the initial lockdown, when only essential workers went to work, and increased thereafter. PM2.5 concentrations were lowered by 45.5%, 46.7%, 82.4%, 72.7% at Kaneshie First Light, Shangri-la, Tantra Hill and Amasaman roadside monitoring locations respectively, compared with 2019 data. This was consistent with measured reductions in mobility during the lock-down. PM10 concentrations for the same four roadside monitoring locations, however, were higher during the lockdown compared to data for the same period in 2019; PM10 concentrations at the industrial monitoring site near the electric power plant were also higher. This increase may have been due to residential biomass burning during stay-at-home orders, or increased electricity production to support home activity. In conclusion, worldwide researches collected pollution data using remote sensing and satellite data where in this study conducted in Ghana pollution data collected on ground-level monitors.