Gelatin Nanofibers in Drug Delivery Systems and Tissue Engineering
Ashni Arun, Pratyusha Malrautu, Anindita Laha and Seeram Ramakrishna
1Department of Chemical Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka, 576104, India
2Center for Nanofibers and Nanotechnology, National University of Singapore, 119260, Singapore
*Corresponding author, Email: anindita.laha19@gmail.com
Abstract
Compared to conventional drug delivery systems (DDS), which show side effects due to uncontrollable properties of drug release, and nonspecific bio-distribution, smart DDS provide a regulated release for prolonged time and improve therapeutic efficacy. On the other hand, tissue engineering (TE) uses a combination of cells and ideal physicochemical and biochemical properties to renew different types of biological tissues. Both cases require an excellent polymer excipient to achieve controlled release of therapeutic agents to provide the correct matrix for cell proliferation. Besides the choice of polymer, the correct polymer excipient design should also be considered which demands the need for nanotechnology. Nanofibers fabricated from natural polymers are versatile due to their properties favorable for usage as scaffolds for TE, gene and drug delivery. Gelatin has been thoroughly looked into for biomedical applications because of its inherent biocompatibility, biodegradability and non-toxicity. In this review, we have focused on the potential of gelatin biopolymer-based nanofiber matrix in the application of DDS and TE.
Publication details
Received: 21 Jul 2021
Revised: 28 Aug 2021
Accepted: 10 Sep 2121
Published online: 10 Sep 2021
Article type:
Review Paper
DOI:
10.30919/es8d527
Volume:
16
Page:
71-81
Citation:
Engineered Science, 2021, 16, 71-81
Permissions:
Copyright
Number of downloads:
3544
Citation Information:
27
Description:
This article is cited by 27 publications.
- Trimeche Monia, Ben Cheikh Ridha. Polymer-ceramic composites for bone challenging applications: Materials and manufacturing processes. Journal of Thermoplastic Composite Materials 2024, 37, 1540, DOI: 10.1177/08927057231190066
- Jianfeng Zhou, Tao Yi, Zhiyuan Zhang, Deng-Guang Yu, Ping Liu, Liangzhe Wang, Yuanjie Zhu. Electrospun Janus core (ethyl cellulose//polyethylene oxide) @ shell (hydroxypropyl methyl cellulose acetate succinate) hybrids for an enhanced colon-targeted prolonged drug absorbance. Advanced Composites and Hybrid Materials 2023, 6, , DOI: 10.1007/s42114-023-00766-6
This article is cited by 27 publications.
- Trimeche Monia, Ben Cheikh Ridha. Polymer-ceramic composites for bone challenging applications: Materials and manufacturing processes. Journal of Thermoplastic Composite Materials 2024, 37, 1540, DOI: 10.1177/08927057231190066
- Jianfeng Zhou, Tao Yi, Zhiyuan Zhang, Deng-Guang Yu, Ping Liu, Liangzhe Wang, Yuanjie Zhu. Electrospun Janus core (ethyl cellulose//polyethylene oxide) @ shell (hydroxypropyl methyl cellulose acetate succinate) hybrids for an enhanced colon-targeted prolonged drug absorbance. Advanced Composites and Hybrid Materials 2023, 6, , DOI: 10.1007/s42114-023-00766-6
- Abdurohman Mengesha Yessuf, Mohamed Bahri, Tibebu Shiferaw Kassa, Bharat Prasad Sharma, Ahmed M. Salama, Changmin Xing, Qidong Zhang, Yong Liu. Electrospun Polymeric Nanofibers: Current Trends in Synthesis, Surface Modification, and Biomedical Applications. ACS Applied Bio Materials 2024, 7, 4231, DOI: 10.1021/acsabm.4c00307
- Tong Liu, Zhimao Li, Tianxiang Jiang, Shaohua Xi, Yingchun Li, Jiang Guo, Mina Huang, Hassan Algadi, Xinming Ye, Qinglong Jiang. Improvement of thermodynamic properties of poly(butanediol sebacate-butanediol terephthalate) (PBSeT) composites based on the dispersion of PCaCO3@tannic acid formed by complexation of tannic acid and Ti. Advanced Composites and Hybrid Materials 2022, 5, 2787, DOI: 10.1007/s42114-022-00564-6
- Panichiyil Valiyaveetil Bhavya, Kamalakannan Soundarajan, Jan Grzegorz Malecki, Thangamuthu Mohan Das. Sugar-Based Phase-Selective Supramolecular Self-Assembly System for Dye Removal and Selective Detection of Cu2+ Ions. ACS Omega 2022, 7, 39310, DOI: 10.1021/acsomega.2c05466
- Lei Gao, Zhongquan Xu, Jiben Qian. Model Test Study on Deformation Monitoring of 3D Printed Snowflake Shaped Pile. IEEE Sensors Journal 2022, 22, 9440, DOI: 10.1109/JSEN.2022.3165158
- J. V. Sanchaniya. Comparative Analysis of Thermal Characteristics: Virgin Polyacrylonitrile (PAN) Versus Electrospun Pan Nanofibre Mats. Latvian Journal of Physics and Technical Sciences 2024, 61, 98, DOI: 10.2478/lpts-2024-0031
- Aliakbar Jafari, Vafa Fakhri, Soosan Kamrani, S. Reza Ghaffarian Anbaran, Chia-Hung Su, Vahabodin Goodarzi, Vahid Pirouzfar, Hossein Ali Khonakdar. Development of Flexible Nanocomposites Based on Poly(ε-caprolactone) for Tissue Engineering Application: The Contributing Role of Poly(glycerol succinic acid) and Polypyrrole. European Polymer Journal 2022, 164, 110984, DOI: 10.1016/j.eurpolymj.2021.110984
- Qiuyang Wang, Lanlan Wang, Xinyun Liu, Haojun Chen, Xucai Wang, Peng Wang, Weijun Wang, Qing Jiang. A pH-responsive magnetic-controlled nanocomposite for precise and efficient vancomycin delivery in treating prosthetic joint infections. Advanced Composites and Hybrid Materials 2025, 8, , DOI: 10.1007/s42114-024-01079-y
- Fatima Bhatti, Ding Xiao, Tara Jebagu, Xiaozhou Huang, Erin Witherspoon, Pei Dong, Sidong Lei, Jie Shen, Zhe Wang. Semiconductive biocomposites enabled portable and interchangeable sensor for early osteoarthritis joint inflammation detection. Advanced Composites and Hybrid Materials 2023, 6, , DOI: 10.1007/s42114-022-00614-z
- Witha Berlian Kesuma Putri, Zakiya Nibras Sausan, Nining Sumawati Asri, Eko Arief Setiadi, Andri Hardiansyah. Characterization of electrospun polyvinylidene fluoride-loaded iron sand-based Fe3O4 nanoparticles. Advances in Natural Sciences: Nanoscience and Nanotechnology 2023, 14, 015003, DOI: 10.1088/2043-6262/acbc70
- J. V. Sanchaniya, G. Moothedath. Deformation Behaviour of Oriented Electrospun Pan Nanofiber Mats. Latvian Journal of Physics and Technical Sciences 2025, 62, 60, DOI: 10.2478/lpts-2025-0013
- Yusheng Yuan, Niclas Solin. Protein-Based Flexible Conductive Aerogels for Piezoresistive Pressure Sensors. ACS Applied Bio Materials 2022, 5, 3360, DOI: 10.1021/acsabm.2c00348
- Unnati Garg, Tanya Dua, Shreya Kaul, Neha Jain, Manisha Pandey, Upendra Nagaich. Enhancing periodontal defences with nanofiber treatment: recent advances and future prospects. Journal of Drug Targeting 2024, 32, 470, DOI: 10.1080/1061186X.2024.2321372
- Xuemei Hu, Junqiang Qiao, Jianping Zhou, Jianqin Bao, Wei He. Enhanced Sonocatalytic Performance of Polyethylene Glycol Modified Hierarchical Cu2ZnSnS4 Microspheres in Methylene Blue Decolorization. Catalysis Letters 2023, 153, 2853, DOI: 10.1007/s10562-022-04204-y
- Aszad Alam, Rounik Karmakar, Aravind Kumar Rengan, Mudrika Khandelwal. Nanofiber-Based Systems for Stimuli-Responsive and Dual Drug Delivery: Present Scenario and the Way Forward. ACS Biomaterials Science & Engineering 2023, 9, 3160, DOI: 10.1021/acsbiomaterials.3c00363
- Sonaimuthu Mohandoss, Kuppu Sakthi Velu, Naushad Ahmad, Ramachandran Srinivasan, Prasanta Roy, Prathap Somu. Polymer-free β-cyclodextrins and mefenamic acid inclusion complex nanofibers for enhanced drug solubility and biomedical applications. Scientific Reports 2025, 15, , DOI: 10.1038/s41598-025-15651-z
- Mingliang Ma, Yan Chen, Jiabin Jiang, Yuxin Bi, Zijian Liao, Yong Ma. One-dimensional recoverable ZnFe2O4/C/MnO2/BiOI magnetic composite with enhanced photocatalytic performance for organic dyes degradation. Environmental Science and Pollution Research 2022, 29, 63233, DOI: 10.1007/s11356-022-20291-1
- Zefeng Wang, Ruixiang Li, Jiange Zhang. On-demand drug delivery of triptolide and celastrol by poly(lactic-co-glycolic acid) nanoparticle/triglycerol monostearate-18 hydrogel composite for rheumatoid arthritis treatment. Advanced Composites and Hybrid Materials 2022, 5, 2921, DOI: 10.1007/s42114-022-00493-4
- Wei Ding, Kanglei Wang, Haiteng Liu, Song Guo, Xiaoyan Pang, Zhiwen Ding. Biomass-Derived Aldehyde and Aminated Graphene Oxide Reinforced Gelatin-Based Composite Films for Biopackaging via a Multipoint Cross-Linking Strategy. ACS Sustainable Chemistry & Engineering 2024, 12, 10624, DOI: 10.1021/acssuschemeng.4c03622
- Yirui Zhao, Hang Yang, Hongshun Hao, Fuxiao Zhu, Gongliang Zhang, Jingran Bi, Shuang Yan, Hongman Hou. Construction of an S-Scheme Ag2MoO4/ZnFe2O4 Nanofiber Heterojunction for Enhanced Photoelectrocatalytic Activity under Visible Light Irradiation. Langmuir 2022, 38, 13437, DOI: 10.1021/acs.langmuir.2c01881
- Rabeya Binta Alam, Md. Hasive Ahmad, S. M. Nazmus Sakib Pias, Eashika Mahmud, Muhammad Rakibul Islam. Improved optical, electrical, and thermal properties of bio-inspired gelatin/SWCNT composite. AIP Advances 2022, 12, , DOI: 10.1063/5.0089118
- NAWZAT D. ALJBOUR, ENAS A. ALKHADER, MOHAMMAD D. BEG. AN OVERVIEW OF NANO-CRYSTALLINE CELLULOSE NANOFIBERS AND THEIR APPLICATIONS IN DRUG DELIVERY. International Journal of Applied Pharmaceutics 2025, , 53, DOI: 10.22159/ijap.2025v17i2.52561
- Aref Yarahmadi, Behrooz Dousti, Mahdi Karami-Khorramabadi, Hamed Afkhami. Materials based on biodegradable polymers chitosan/gelatin: a review of potential applications. Frontiers in Bioengineering and Biotechnology 2024, 12, , DOI: 10.3389/fbioe.2024.1397668
- Bin Wang, Muqing Liu, Jinbo Liu, Yuan Tian, Wentao Liu, Gensheng Wu, Jie Cheng, Yi Zhang, Gutian Zhao, Zhonghua Ni. Key Factors of Mechanical Strength and Toughness in Oriented Poly(l-lactic acid) Monofilaments for a Bioresorbable Self-Expanding Stent. Langmuir 2022, 38, 13477, DOI: 10.1021/acs.langmuir.2c01972
- Jia-Qi Hu, Jing Wang, Zhen-Hua Shen, Yu-Xian Lai, Jia-Yin You, Qiang Yan, Ke-Feng Ren, Jian Ji. Mechanical Enhancement of the Gelatin/Poly(zinc acrylate) Hydrogel Stent in Bile. ACS Applied Bio Materials 2023, 6, 5621, DOI: 10.1021/acsabm.3c00786
- Mithilesh Kogje, Ajinkya Satdive, Siddhesh Mestry, S. T. Mhaske. Biopolymers: a comprehensive review of sustainability, environmental impact, and lifecycle analysis. Iranian Polymer Journal 2025, 34, 1481, DOI: 10.1007/s13726-024-01449-9
General Links :
Copyright © 2025 Engineered Science Publisher, All Rights Reserved