Numerical Modeling of Ultrasound-Induced Tissue Deformation and Thermal Effects for Muscle Pain and Office Syndrome with a Focus on Frequency-Dependent Therapeutic Outcomes
Abstract
This study uses advanced numerical modeling to examine ultrasound waves' effects on muscle tissue and optimize treatment parameters like frequency and exposure length to improve therapeutic efficacy. The COMSOL Multiphysics model accurately simulates tissue mechanical and thermal reactions to ultrasonic stimulation by integrating acoustic wave propagation, viscoelastic tissue deformation, and bioheat transfer equations. Lower ultrasound frequencies (1.0 MHz) induce greater peak mechanical displacement, promoting deeper tissue penetration, while higher frequencies (1.5 MHz) produce a more uniform but reduced deformation gradient, optimizing localized therapeutic effects and minimizing tissue stress. The model confirms a time-dependent dissipation effect in which tissue adapts to prolonged ultrasonic treatment, diminishing mechanical sensitivity. Further, bioheat transfer research shows that ultrasound-induced heating follows Fourier's Law, with energy dissipation mediated by conduction and blood perfusion. This study reduces human and animal experiments by using numerical models to anticipate therapeutic outcomes and ensure patient safety in early treatment planning. The findings demonstrate the therapeutic viability of non-invasive, drug-free ultrasound therapy, eliminating surgical and medication risks. These findings improve muscle pain and office syndrome ultrasound therapy methods, laying the groundwork for individualized and effective treatment.