Infill drilling is a strategic method to improve hydrocarbon extraction and enhance field performance from mature oilfields, using strategies that involve an all-inclusive comprehension of reservoir dynamics. This study utilizes a meticulous reservoir-based simulation methodology for infill well positioning. Advanced modelling techniques were used to simulate three different scenarios involving two theoretical wells, Infill 1X and Infill 2X, to evaluate how strategically placed infill wells affect production rates. Other reservoir and well parameters considered include water-cut, average permeability at the perforation interval, reservoir pressure, and production rates. The Infill 1X well, located in a region with exceptionally high average permeability, is expected to generate a greater total amount of oil output over time. Nevertheless, the management of well production rates is essential for maintaining uninterrupted production and addressing concerns related to water-cut and gas-oil ratio (GOR) problems, as demonstrated by the performance of Infill 2X. The simulation results are further validated by applying the Darcy flow equation, which strengthens the conclusion that permeability plays a crucial role in hydrocarbon recovery. The study offers practical insights into the most effective positioning and operational control of infill wells, providing a strategy to rejuvenate mature oil fields and optimize extraction efficiency.