Synthesis and Biological Activity of Some Esters of Glycyrretinic Acid
Abstract
Synthetic transformations of bioactive natural compounds are one of the current areas of modern organic and bioorganic chemistry associated with the search for new structural types, substances and compounds with a wide range of biological activity. One of these natural compounds is 3β-hydroxy-11-oxo-12-en-18βН, 20β-olean-30 acid, 3-О-(2҆-О-β-D glucuronopyranosyl)-β-D-glucuronopyranoside (glycyrrhizic acid, GA) is the main active principle of licorice root (Glycyrrhiza glabra L.), which grows on the territory of the Republic of Uzbekistan and is a renewable natural source. With the ability to self-organize and recognize other particles and molecules, natural biologically active compounds are the subject of current chemical research aimed at modeling various biochemical processes. Various esters of Glycyrrhetic acid derivatives were synthesized. The chemical structures of the synthesized compounds were confirmed by ultraviolet (UV), infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR) spectroscopy (13С and 1Н). Substance 1 exhibits antiproliferative activity on HeLa cells. The inclusion of MTT in cells at 100 µl/ml of the medium is 55.21%, i.e., inhibition of cell growth is 44.8%.