Malaria remains a major global health issue, with persistent challenges undermining control and eradication efforts. This paper focuses on the epidemiological trends and public health strategies in malaria control, examining the complex interaction of biological, environmental, socioeconomic, and political factors that impact malaria transmission and intervention effectiveness. In regions with high transmission intensity, the fight against malaria is compounded by issues such as drug resistance, insecticide resistance, inadequate healthcare infrastructure, and limited financial resources. Despite advancements in diagnostic tools, treatment options, and vector control interventions, malaria continues to be a leading cause of morbidity and mortality, particularly in sub-Saharan Africa. Public health strategies for malaria control are multifaceted and require integrated approaches that combine vector control, early diagnosis, effective treatment, and preventive measures such as insecticide-treated nets (ITNs) and indoor residual spraying (IRS). Recent developments in malaria vaccines and community-based interventions show promise, but challenges such as resistance to treatment, logistical constraints, and the need for greater community participation persist. The success of malaria control programs depends on addressing these barriers while ensuring equitable access to interventions. Collaboration between governments, international organizations, and local communities is essential to combat malaria effectively. Understanding the evolving epidemiology of malaria, including the impacts of climate change, population movement, and urbanization, is critical for adapting strategies and ultimately achieving global malaria elimination goals.